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her 4  (Danaher Inc)


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    Structured Review

    Danaher Inc her 4
    Her 4, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/her+4/pm39111120-464-23-25
    Average 86 stars, based on 1 article reviews
    her 4 - by Bioz Stars, 2026-10
    86/100 stars

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    Related Articles

    Kinase Assay:

    Article Title: Design, synthesis and biological evaluation of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors bearing a heterocyclic-containing tail as potential anti-tumor agents.
    Article Snippet: A series of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors were designed and synthesized by heterocyclic-containing tail approach.. The inhibitory activities against four human epidermal growth factor receptor (HER) isozymes (EGFR, HER-2, HER-3 and HER-4) of all new compounds so designed were investigated in vitro.. Compound 12k was found to be the most effective and rather selective dual-target inhibitor of EGFR and HER-2 with inhibitory constant (IC50) values of 6.15 and 9.78 nM, respectively, which was more potent than the clinical used agent Lapatinib (IC50 = 8.41 and 9.41 nM).

    Article Title: Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis.
    Article Snippet: Targeting EGFR and HER-2 is an essential direction for cancer treatment.. Here, a series of N-(1,3,4-thiadiazol-2yl)benzamide derivatives containing a 6,7-methoxyquinoline structure was designed and synthesized to serve as EGFR/HER-2 dual-target inhibitors.. The kinase assays verified that target compounds could inhibit the kinase activity of EGFR and HER-2 selectively.

    Activity Assay:

    Article Title: Design, synthesis and biological evaluation of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors bearing a heterocyclic-containing tail as potential anti-tumor agents.
    Article Snippet: A series of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors were designed and synthesized by heterocyclic-containing tail approach.. The inhibitory activities against four human epidermal growth factor receptor (HER) isozymes (EGFR, HER-2, HER-3 and HER-4) of all new compounds so designed were investigated in vitro.. Compound 12k was found to be the most effective and rather selective dual-target inhibitor of EGFR and HER-2 with inhibitory constant (IC50) values of 6.15 and 9.78 nM, respectively, which was more potent than the clinical used agent Lapatinib (IC50 = 8.41 and 9.41 nM).

    Article Title: Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis.
    Article Snippet: Targeting EGFR and HER-2 is an essential direction for cancer treatment.. Here, a series of N-(1,3,4-thiadiazol-2yl)benzamide derivatives containing a 6,7-methoxyquinoline structure was designed and synthesized to serve as EGFR/HER-2 dual-target inhibitors.. The kinase assays verified that target compounds could inhibit the kinase activity of EGFR and HER-2 selectively.

    Concentration Assay:

    Article Title: Design, synthesis and biological evaluation of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors bearing a heterocyclic-containing tail as potential anti-tumor agents.
    Article Snippet: A series of novel quinazoline-derived EGFR/HER-2 dual-target inhibitors were designed and synthesized by heterocyclic-containing tail approach.. The inhibitory activities against four human epidermal growth factor receptor (HER) isozymes (EGFR, HER-2, HER-3 and HER-4) of all new compounds so designed were investigated in vitro.. Compound 12k was found to be the most effective and rather selective dual-target inhibitor of EGFR and HER-2 with inhibitory constant (IC50) values of 6.15 and 9.78 nM, respectively, which was more potent than the clinical used agent Lapatinib (IC50 = 8.41 and 9.41 nM).

    Article Title: Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis.
    Article Snippet: Targeting EGFR and HER-2 is an essential direction for cancer treatment.. Here, a series of N-(1,3,4-thiadiazol-2yl)benzamide derivatives containing a 6,7-methoxyquinoline structure was designed and synthesized to serve as EGFR/HER-2 dual-target inhibitors.. The kinase assays verified that target compounds could inhibit the kinase activity of EGFR and HER-2 selectively.



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    Immunohistochemical expression of HER family members in osteosarcoma specimens. (A) High EGFR expression: Predominantly membranous with some cytoplasmic brown staining (arrow). (B) Low EGFR expression. (C) High HER-2 expression: Predominantly cytoplasmic brown staining (arrow). (D) Low HER-2 expression. (E) High HER-3 expression: Predominantly nuclear and cytoplasmic brown staining (arrow). (F) Low HER-3 expression. (G) High <t>HER-4</t> expression: Predominantly nuclear and cytoplasmic brown staining (arrow). (H) Low HER-4 expression. (I) Final HER expression score demonstrating no significant difference among the expression levels of the HER family members. The box-plot was obtained using GraphPad Prism 5.0 (GraphPad Software Inc., San Diego, CA, USA) (original magnification of Fig. A-H, ×200). HER, human epidermal growth factor receptor.
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    Image Search Results


    Immunohistochemical expression of HER family members in osteosarcoma specimens. (A) High EGFR expression: Predominantly membranous with some cytoplasmic brown staining (arrow). (B) Low EGFR expression. (C) High HER-2 expression: Predominantly cytoplasmic brown staining (arrow). (D) Low HER-2 expression. (E) High HER-3 expression: Predominantly nuclear and cytoplasmic brown staining (arrow). (F) Low HER-3 expression. (G) High HER-4 expression: Predominantly nuclear and cytoplasmic brown staining (arrow). (H) Low HER-4 expression. (I) Final HER expression score demonstrating no significant difference among the expression levels of the HER family members. The box-plot was obtained using GraphPad Prism 5.0 (GraphPad Software Inc., San Diego, CA, USA) (original magnification of Fig. A-H, ×200). HER, human epidermal growth factor receptor.

    Journal:

    Article Title:

    doi:

    Figure Lengend Snippet: Immunohistochemical expression of HER family members in osteosarcoma specimens. (A) High EGFR expression: Predominantly membranous with some cytoplasmic brown staining (arrow). (B) Low EGFR expression. (C) High HER-2 expression: Predominantly cytoplasmic brown staining (arrow). (D) Low HER-2 expression. (E) High HER-3 expression: Predominantly nuclear and cytoplasmic brown staining (arrow). (F) Low HER-3 expression. (G) High HER-4 expression: Predominantly nuclear and cytoplasmic brown staining (arrow). (H) Low HER-4 expression. (I) Final HER expression score demonstrating no significant difference among the expression levels of the HER family members. The box-plot was obtained using GraphPad Prism 5.0 (GraphPad Software Inc., San Diego, CA, USA) (original magnification of Fig. A-H, ×200). HER, human epidermal growth factor receptor.

    Article Snippet: The sections were then immunostained with anti-EGFR (rabbit monoclonal EP38Y; cat no. ab52894; 1:50 dilution), anti-HER-2 (mousemonoclonalHRB2/451; cat no. ab187288; 1:100 dilution), anti-HER-3 (mouse monoclonalRTJ2; cat no. ab20161; 1:50 dilution) or anti-HER-4 (mouse monoclonal5G6B4; cat. no. ab204959; 1:50 dilution) (all Abcam, Cambridge, MA, USA) and incubated overnight at 4°C.

    Techniques: Immunohistochemical staining, Expressing, Staining, Software

    Kaplan-Meier analyses of PFS and OS time in stage I–IIB osteosarcoma patients. Significant differences in (A) PFS (P=0.033) and (B) OS (P=0.041) time were found between the high and low EGFR expression groups. Significant differences in (C) PFS (P=0.001) and (D) OS (P=0.006) time were found between the high and low HER-3 expression groups. Significant differences in (E) PFS (P=0.010) and (F) OS (P=0.015) time were found between the high and low HER-4 expression groups. HER, human epidermal growth factor receptor; PFS, progression-free survival; OS, overall survival.

    Journal:

    Article Title:

    doi:

    Figure Lengend Snippet: Kaplan-Meier analyses of PFS and OS time in stage I–IIB osteosarcoma patients. Significant differences in (A) PFS (P=0.033) and (B) OS (P=0.041) time were found between the high and low EGFR expression groups. Significant differences in (C) PFS (P=0.001) and (D) OS (P=0.006) time were found between the high and low HER-3 expression groups. Significant differences in (E) PFS (P=0.010) and (F) OS (P=0.015) time were found between the high and low HER-4 expression groups. HER, human epidermal growth factor receptor; PFS, progression-free survival; OS, overall survival.

    Article Snippet: The sections were then immunostained with anti-EGFR (rabbit monoclonal EP38Y; cat no. ab52894; 1:50 dilution), anti-HER-2 (mousemonoclonalHRB2/451; cat no. ab187288; 1:100 dilution), anti-HER-3 (mouse monoclonalRTJ2; cat no. ab20161; 1:50 dilution) or anti-HER-4 (mouse monoclonal5G6B4; cat. no. ab204959; 1:50 dilution) (all Abcam, Cambridge, MA, USA) and incubated overnight at 4°C.

    Techniques: Expressing

    Kaplan-Meier analyses of PFS and OS time in stage IIB osteosarcoma patients. Significant differences of PFS time were found between the high and low (A) HER-4 (P=0.002) expression groups and (B) EGFR/HER-4 (P<0.001) expression groups. Significant differences of OS time were found between the high and low (C) HER-4 (P=0.011) expression groups and (D) EGFR/HER-4 (P<0.001) expression groups. HER, human epidermal growth factor receptor; PFS, progression-free survival; OS, overall survival.

    Journal:

    Article Title:

    doi:

    Figure Lengend Snippet: Kaplan-Meier analyses of PFS and OS time in stage IIB osteosarcoma patients. Significant differences of PFS time were found between the high and low (A) HER-4 (P=0.002) expression groups and (B) EGFR/HER-4 (P<0.001) expression groups. Significant differences of OS time were found between the high and low (C) HER-4 (P=0.011) expression groups and (D) EGFR/HER-4 (P<0.001) expression groups. HER, human epidermal growth factor receptor; PFS, progression-free survival; OS, overall survival.

    Article Snippet: The sections were then immunostained with anti-EGFR (rabbit monoclonal EP38Y; cat no. ab52894; 1:50 dilution), anti-HER-2 (mousemonoclonalHRB2/451; cat no. ab187288; 1:100 dilution), anti-HER-3 (mouse monoclonalRTJ2; cat no. ab20161; 1:50 dilution) or anti-HER-4 (mouse monoclonal5G6B4; cat. no. ab204959; 1:50 dilution) (all Abcam, Cambridge, MA, USA) and incubated overnight at 4°C.

    Techniques: Expressing